In response to analytical needs in connection with the SARS CoV 2 pandemic (COVID-19), the NIH Office of Portfolio Analysis (OPA) has developed a comprehensive, expert-curated portfolio of COVID-19 publications and preprints. Our iSearch COVID-19 portfolio, which includes peer-reviewed articles from PubMed and preprints from arXiv, bioRxiv, ChemRxiv, medRxiv, Preprints.org, Qeios, Research Square, and SSRN. The portfolio is updated daily with the latest available data. This resource enables users to explore and analyze the rapidly growing set of advances in either COVID-19 or the novel coronavirus SARS-CoV-2 research as they accumulate in real time, and complements efforts by NLM to aggregate full text documents broadly related to COVID-19, the novel coronavirus SARS-CoV-2, or other outbreaks, and articles on COVID-19 or SARS-CoV-2 specific to the PubMed database.